Subsequence and distant supervision based active learning for relation extraction of Chinese medical texts.

In recent years, relation extraction on unstructured texts has become an important task in medical research. However, relation extraction requires a large amount of labeled corpus, manually annotating sequences is time consuming and expensive. Therefore, efficient and economical methods for annotating sequences are required to ensure the performance of relational extraction. This paper proposes a method of subsequence and distant supervision based active learning. The method is annotated by selecting information-rich subsequences as a sampling unit instead of the full sentences in traditional active learning. Additionally, the method saves the labeled subsequence texts and their corresponding labels in a dictionary which is continuously updated and maintained, and pre-labels the unlabeled set through text matching based on the idea of distant supervision. Finally, the method combines a Chinese-RoBERTa-CRF model for relation extraction in Chinese medical texts. Experimental results test on the CMeIE dataset achieves the best performance compared to existing methods. And the best F1 value obtained between different sampling strategies is 55.96%.

[Use of a Guidebook for Stroke Patients to Promote Health and Employment Support].

When stroke patients consider a return to work, several difficulties are encountered regarding the promotion of support for both their health and employment due to the different perspectives of the patients, their families, and medical institutions. The Japanese Ministry of Health, Labour and Welfare has published a guideline for medical institutions and offices, but not for stroke patients or their families. As a result, patients and their families do not know how to process both medical treatments and their work after the occurrence of a stroke. We have therefore published the "Guidebook for Stroke Patients to Promote Health and Employment Support" based on the concept of the previously published "Guidebook for Cancer Patients for Promoting Health and Employment Support". This publication offers an overview of stroke and the flow from stroke onset to return to work. Patients can confirm how they should be handled at different phases of stroke. A stroke affects the patient, their family, and the individuals providing support, so this publication offers an information tool to facilitate the participation of stroke patients in society. The guide can thus be expected to contribute to an increased rate of return to work by stroke patients.

[Gender blindness in medical textbooks: the case of leukemias]. / Ceguera de género en los libros de texto de medicina. El caso de las leucemias.

OBJECTIVE: To analyse the existence of sex-differences in the content on leukemias in the Haematology and Internal Medicine textbooks recommended in the Medical Degrees, 2019-2020, by comparison with the sex-differences recognized in the scientific literature. METHOD: Manifest content analysis of the content of chapters on leukemias in the books on hematology and internal medicine, clinical haematology and haematology undergraduate. Analysis categories: epidemiology, etiopathogenesis, diagnosis, treatment and prognosis of leukemias. RESULTS: Epidemiological information from the revised books has a greater consideration of sex differences in incidence and prognosis but does not contain data on mortality and survival. Etiopathogenesis is described in all books as the same physiological process for both sexes and no differences in the presentation of symptoms are described in any book. Three books describe a unique treatment that is assumed equal for both sexes; two books mention the treatment of acute myeloid leukemia in pregnant women and one in chronic myeloid leukemia. No book mentions sex-differences in pharmacokinetics, efficacy, or treatment toxicity, although there is greater evidence on unequal behavior between the sexes. CONCLUSIONS: The contents of sex and gender differences in the leukemia chapters analyzed are insufficient compared to the evidence in the scientific literature today. Hematology textbooks might increase their scientific quality in future editions, including knowledge of sex-gender interaction in the sections of epidemiology, etiology, pathogenesis, diagnosis, treatment, prognosis, and consequences of leukemias, which will contribute to better professional practices, more efficient and equitable.

The interpretation of human body in traditional Chinese medicine and its influence on the characteristics of TCM theory.

Traditional Chinese medicine (TCM) has a long history of serving the Chinese people's health since its birth, including playing an important role in treating and preventing COVID-19 in 2020. The fact that TCM has been used in China for thousands of years shows the value and reason why it must exist. Although TCM has been or is being questioned, there is no doubt about its importance in terms of efficacy. This article focuses on how TCM understands the human body in comparison with anatomy knowledge in western medicine and discusses the development and advances of TCM in terms of the body view and the theory innovation. The purpose is to let foreign scholars get better understanding of TCM from this perspective.

A Study on Head Wounds in Kitab al-'Umda fi Sina'a al-Jiraha by Ibn al-Quff.

The aim of this study is to investigate the knowledge on head wounds contained in the Kitab al-'Umda fi Sina'a al-Jiraha, written by Ibn al-Quff in the thirteenth century. This study was based on a copy of the Kitab al-'Umda fi Sina'a al-Jiraha, printed in 2 volumes in Da'ira al-Ma'arif al-Uthmaniyya in Hyderabad in 1356/1937-38 and reprinted by the Institute for the History of Arabic-Islamic Science at the Johann Wolfgang Goethe University. This printed copy was compared with the manuscript of Istanbul University Rare Works Library, Arabic Manuscripts, A 4749. Relevant chapters were translated from Arabic to English, after which they were thoroughly examined. Obtained knowledge is presented in the Results section and is compared in the Discussion section with other reports of this subject. The first chapter classified head wounds into 6 types: the first 3 types are conservatively treated and the remaining 3 types are surgically treated. This chapter also presents information on how to proceed when there is a head wound-related hemorrhage, which medications should be used, and which are the adequate treatment protocols. The second chapter discusses the symptoms and signs that follow head blow and fall injuries. The characteristics and noteworthy circumstances of skull fractures as well as the surgical treatment methods are included in the fifteenth chapter, which is concluded with surgery-related complications. The present study shows that Ibn al-Quff benefited from his predecessors' knowledge and made some considerable contributions to this subject.

Las traducciones argentinas de Galeno: el caso de La Sangría / Translations of Galen in argentina: the case of la sangria

El presente trabajo estudia las primeras traducciones de Galeno al español que se realizaron en Argentina, en el marco de un proyecto editorial dirigido por Aníbal Ruiz Moreno. La investigación pone de manifiesto que la colección en la que aparecen no era en realidad solo de obras de Galeno, sino una colección general con textos relevantes para la historia de la medicina. Se añade el caso concreto de La sangría como estudio de caso para una evaluación preliminar de la naturaleza de las traducciones ofrecidas por Ruiz Moreno y su equipo. El proyecto quedó inconcluso debido a la repentina muerte de su director por lo que quedaron algunos tratados galénicos sin publicar. El artículo aporta una hipótesis plausible sobre el destino de estas traducciones. Aníbal Ruiz Moreno, fue nada menos que el fundador, junto con Pedro Laín Entralgo, de la revista que hoy se llama Asclepio.(AU)

This paper studies the first translations of Galen’s works into Spanish which were made in Argentina, within the framework of an editorial project directed by Aníbal Ruiz Moreno. The study shows that the collection in which they appear did not only publish Galen’s treatises. It was rather a general collection with texts relevant to the history of medicine. The specific case of La sangría is added as a case study for a preliminary evaluation of the nature of the translations offered by Ruiz Moreno and his team. This project was left unfinished due to the sudden death of its director, so some Galenic treatises remained unpublished. The article provides a plausible hypothesis about the fate of these translations. Aníbal Ruiz Moreno, was no less than the founder, together with Pedro Laín Entralgo, of the magazine that today is called Asclepio.(AU)

"Not Just for Doctors Anymore": How the Merck Manual Became a Consumer Health "Bible".

The transformation of the Merck Manual of Diagnosis and Therapy from a "doctors-only" reference into a consumer health bible illuminates a critical era in the history of the twentieth-century medical book. Merck and Company restricted sales of its Merck Manual, first published in 1899 to offer up-to-date information for the busy practitioner, to physicians and other health care professionals until the 1970s. As more laypeople sought to get involved in their own health care decision making, the Merck Manual developed a devoted following. In the late 1980s, with almost a quarter of its sales going to nonphysicians, Merck and Company decided to put out a home edition of its famous manual. This evolution provides important insights into both the history of the medical book and the doctor-patient relationship in the United States.

Los primeros 100 años de la patología clínica en el Perú: 1856 ­ 1956 / The first 100 years of clinical pathology in Peru: 1856-1956

La publicación es una recopilación de hechos cronológicos relacionados a la especialidad, desde los antecedentes de su nacimiento y el avance en estos largos años; es gratificante conocer en esta obra el valioso aporte de médicos peruanos y también la de grandes investigadores extranjeros, que enriquecieron el conocimiento de nuestra especialidad. El inicio de las cátedras relacionadas al Laboratorio Clínico en la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos, el descubrimiento del agente etiológico de la enfermedad de Carrión, las semblanzas biográficas de renombrados médicos que se dedicaron a este quehacer, el primer Patólogo Clínico en el Perú, y la presencia de la especialidad en el Perú y América Latina, nos hará transpolar a esos años.

[Discrepancies in medical textbooks and their impact on medical school students]. / Discordances entre les référentiels des collèges d'enseignants en médecine et leur impact sur les étudiants en médecine.

BACKGROUND: Textbooks endorsed by national medical specialty societies and colleges are used as official references for faculty and national examinations. Oncology is transdisciplinary, practiced and taught by oncologists but also by other specialists. We aimed at identifying discrepancies between chapters on cancers in different official specialty textbooks and evaluating their impact on students. MATERIAL AND METHODS: Volunteer 6th-year medical students of the Sorbonne University faculty were paired and asked to list the discrepancies between all official specialty textbooks addressing a given cancer and then individually asked to evaluate the impact of discrepancies on their learning experience. RESULTS: In March 2018, the 17 cancers listed in the French medical school education program were addressed in 14 official specialty textbooks (2 to 4 textbooks/cancer). Out of a class of 390 students, 78 volunteered and were paired; each cancer was analyzed by 3 pairs of students (1 or 2 cancers/pair); 154 discrepancies were reported (range: 4-18 per cancer). Discrepancies induced doubt and anxiety in students; 85% considered that harmonization should be achieved for all topics of the national medical school program. CONCLUSIONS: Discrepancies between official textbook are frequent, generate anxiety in students and impact learning experience.

National Socialist Medical Literature and the Censorship Practices in the Soviet Occupation Zone and Early East German State.

This study examines how medical discourse and culture were affected by the denazification policies of the Soviet occupation authorities in East Germany. Examining medical textbooks in particular, it reveals how the production and dissemination of medical knowledge was subject to a complex process of negotiation among authors, publishers, and censorship officials. Drawing on primary-source material produced by censorship authorities that has not been rigorously examined to date, it reveals how knowledge production processes were structured by broader ideological and political imperatives. It thus sheds new light on a unique chapter in the history of censorship.

Data Mining a Medieval Medical Text Reveals Patterns in Ingredient Choice That Reflect Biological Activity against Infectious Agents.

The pharmacopeia used by physicians and laypeople in medieval Europe has largely been dismissed as placebo or superstition. While we now recognize that some of the materia medica used by medieval physicians could have had useful biological properties, research in this area is limited by the labor-intensive process of searching and interpreting historical medical texts. Here, we demonstrate the potential power of turning medieval medical texts into contextualized electronic databases amenable to exploration by the use of an algorithm. We used established methodologies from network science to reveal patterns in ingredient selection and usage in a key text, the 15th-century Lylye of Medicynes, focusing on remedies to treat symptoms of microbial infection. In providing a worked example of data-driven textual analysis, we demonstrate the potential of this approach to encourage interdisciplinary collaboration and to shine a new light on the ethnopharmacology of historical medical texts.IMPORTANCE We used established methodologies from network science to identify patterns in medicinal ingredient combinations in a key medieval text, the 15th-century Lylye of Medicynes, focusing on recipes for topical treatments for symptoms of microbial infection. We conducted experiments screening the antimicrobial activity of selected ingredients. These experiments revealed interesting examples of ingredients that potentiated or interfered with each other's activity and that would be useful bases for future, more detailed experiments. Our results highlight (i) the potential to use methodologies from network science to analyze medieval data sets and detect patterns of ingredient combination, (ii) the potential of interdisciplinary collaboration to reveal different aspects of the ethnopharmacology of historical medical texts, and (iii) the potential development of novel therapeutics inspired by premodern remedies in a time of increased need for new antibiotics.

Stereoscopy in Surgical Neuroanatomy: Past, Present, and Future.

Since the dawn of antiquity, scientists, philosophers, and artists have pondered the nature of optical stereopsis-the perception of depth that arises from binocular vision. The early 19th century saw the advent of stereoscopes, devices that could replicate stereopsis by producing a 3D illusion from the super-imposition of 2D photographs. This phenomenon opened up a plethora of possibilities through its usefulness as an educational tool-particularly in medicine. Before long, photographers, anatomists, and physicians were collaborating to create some of the first stereoscopic atlases available for the teaching of medical students and residents. In fields like neurosurgery-where a comprehensive visuospatial understanding of neuro-anatomical correlates is crucial-research into stereoscopic modalities are of fundamental importance. Already, medical institutions all over the world are capitalizing on new and immersive technologies-such as 3D intraoperative recording, and 3D endoscopes-to refine their pedagogical efforts as well as improve their clinical capacities. The present paper surveys the history of stereoscopy from antiquity to the modern era-with a focus on its role in neurosurgery and medical education. Through the tracking of this evolution, we can discuss potential benefits, future directions, and highlight areas in which further research is needed. By anticipating these factors, we may strive to take full advantage of an emergent field of technology, for our ultimate goal of improving patient care.

The Development of Necrotizing Enterocolitis Publications: A Holistic Evolution of Global Literature with Bibliometric Analysis.

INTRODUCTION: Despite the fact that necrotizing enterocolitis (NEC) is one of the reasons for morbidity and mortality in the newborn intensive care units, the literature indicates no bibliometric studies that made a holistic evaluation of the publications on this issue. This study aims to make a holistic evaluation of NEC publications to reveal the latest developments and trend topics. MATERIALS AND METHODS: Bibliometric analyses were performed by retrieving all the publications in Web of Science (WoS: Web of Science Core Collection database maintained by Clarivate Analytics) database between 1980 and 2018 using the "necrotizing enterocolitis" keyword. The correlations between economic productivity, humanity index, and performances of the countries on the topic of NEC were investigated with Spearman's correlation coefficient. RESULTS: A review of the related literature indicated 2,968 publications on NEC between 1980 and 2018. Of these publications, 1,690 (56.9%) were indexed in the article document category in WoS. There was an important increasing trend in the number of publications after 2006. Results of the present study showed that the Journal of Pediatric Surgery and Journal of Pediatrics were the top effective journal that contributed to the literature in terms of publication productivity. The top productive country that produced most publications about NEC was the United States (863, 51.1%). CONCLUSION: Research on NEC is conducted in a limited number of countries. There seem to be more research opportunities in the developed countries because survival rates of premature babies having a disease like NEC are lower in the undeveloped countries, and survival rates are higher in developed countries due to appropriate intensive care conditions. Therefore, undeveloped countries should be supported in terms of NEC and provided with funds.

José Ángel Bustamante O' Leary. Paradigma de la Psiquiatria Cubana / Jose Ángel Bustamante O' Leary. Paradigma de la Psiquiatria Cubana

RESUMEN El profesor José Ángel Bustamante O' Leary fue un eminente psiquiatra y psicólogo cubano. El presente trabajo tiene como objetivo lograr un acercamiento a la vida y obra de este incansable médico que se dedicó, hasta pocos días antes de su muerte, a brindar sus conocimientos para la formación de los profesionales de la psiquiatría cubana y Latinoamericana. Se realizó una investigación de su trayectoria revolucionaria, académica, científica y asistencial. Los actuales médicos y especialmente los psiquiatras defienden con orgullo los aportes de este consagrado científico en la lucha por la salud mental y el bienestar de los pacientes (AU).

SUMMARY Professor José Ángel Bustamante O' Leary was an eminent Cuban psychiatrist and psychologist. This work is aimed to approaching life and work of this tireless doctor, who devoted himself and his knowledge to the training of Cuban and Latin American professionals of Psychiatry until a few days before his death. The authors researched his revolutionary, academic, scientific and welfare trajectory. Current physicians, especially current psychiatrists proudly defend the contribution of this consecrated scientist to the fight for the mental health and well-being of the patients (AU).

The Texture of Rare and Common Lesions in Soemmerring and Baillie.

The publications on morbid anatomy by Matthew Baillie and Samuel Thomas Soemmerring put pathological preparations and images center stage. A comparison between their works highlights major shifts from exceptional to more representative cases and significant differences in the art of representation. Initially Baillie provided careful descriptions of internal postmortem lesions (1793). Then Soemmerring's prompt German translation added a wealth of references to the literature and specifically to pathological images available in print (1794). Soon after a second unillustrated edition incorporating some of Soemmerring's comments (1797), Baillie issued ten installments with dozens of pathological plates (1799-1803). His plates differed from those referred to by Soemmerring for their broader scope, representing common and rare conditions alike, and specific attention to the fine changes of texture of the affected parts. Their works document the crucial status of pathological preparations and images at the time and highlight the achievement of Baillie's work at an artistic as well as at an intellectual level.

Terminologia Histologica 10 years on: some disputable terms in need of discussion and recent developments.

At first sight, the issue of morphological terminology may seem to be a "closed and unchanging chapter", as many of the structures within the human body have been known for decades or even centuries. However, the exact opposite is true. The initial knowledge of the microscopic structure of the human body has been continuously broadening thanks to the development of new specialized staining techniques, discovery of the electron microscope, or later application of histochemical and immunohistochemical methods into routine tissue examination. Contrary to popular belief, histology has a status of constantly developing scientific discipline, with continuous influx of new knowledge, resulting in an unavoidable necessity to revise the histological nomenclature at regular intervals. The team of experts of the Federative International Programme on Anatomical Terminology, a working group of the International Federation of Associations of Anatomists, published in 2008 the First Edition of Terminologia Histologica. Terminologia Histologica (TH) is the best and most extensive of all the histological nomenclatures ever issued. However, here we suggest that several terms of important histological structures are still missing while several other terms are disputable. First, we present some clinically important terms of cells and tissue structures for inclusion in the next TH and, in a second part, we refer to some new terms in the current edition of the TH which are not yet mentioned in current histology textbooks (e.g., fusocellular connective tissue, bundle bone as the third type of bone tissue, spongy layer of vagina or arteria vaginata from the splenic white pulp). With this article we hope to start a wide scientific discussion which will lead to an inambiguous definition and demonstration of typical examples of all terms in the TH, with the result that the new edition of the Terminologia Histologica will become an internationally accepted communication tool for all practitioners and teachers of histology alike.